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Titel:

Differences in caffeine and paraxanthine metabolism between human and murine CYP1A2.

Dokumenttyp:
Comparative Study; Journal Article; Article
Autor(en):
Labedzki, A; Buters, J; Jabrane, W; Fuhr, U
Abstract:
For the characterisation of murine models of CYP1A2 mediated metabolism in humans we compared the metabolism of caffeine and paraxanthine in human liver microsomes (LM) (two samples) and in LM from CYP1A2-null and wild-type mice. Inhibition experiments were carried out with the quinolones norfloxacin and pefloxacin and the substrate, caffeine. Additionally, in vivo pharmacokinetics of paraxanthine was determined in CYP1A2-null and wild-type mice. All LM produced the primary metabolites of caffei...     »
Zeitschriftentitel:
Biochem Pharmacol
Jahr:
2002
Band / Volume:
63
Heft / Issue:
12
Seitenangaben Beitrag:
2159-67
Sprache:
eng
Volltext / DOI:
doi:10.1016/s0006-2952(02)01019-5
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12110375
Print-ISSN:
0006-2952
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
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