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Titel:

Cytochrome P450 1B1 determines susceptibility to dibenzo[a,l]pyrene-induced tumor formation.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Article
Autor(en):
Buters, JT; Mahadevan, B; Quintanilla-Martinez, L; Gonzalez, FJ; Greim, H; Baird, WM; Luch, A
Abstract:
Metabolic activation, DNA binding, and tumorigenicity of the carcinogenic polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene (DB[a,l]P) catalyzed by murine cytochrome P450 (P450) enzymes were investigated. DNA binding of DB[a,l]P in human mammary carcinoma MCF-7 and human P450-expressing Chinese hamster V79 cell lines was previously shown to occur preferentially with metabolically generated fjord region DB[a,l]P-11,12-dihydrodiol 13,14-epoxides (DB[a,l]PDE). To elucidate different capabilities o...     »
Zeitschriftentitel:
Chem Res Toxicol
Jahr:
2002
Band / Volume:
15
Heft / Issue:
9
Seitenangaben Beitrag:
1127-35
Sprache:
eng
Volltext / DOI:
doi:10.1021/tx020017q
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12230405
Print-ISSN:
0893-228X
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
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