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Title:

Cytochrome P4501B1 mediates induction of bone marrow cytotoxicity and preleukemia cells in mice treated with 7,12-dimethylbenz[a]anthracene.

Document type:
Journal Article; Research Support, U.S. Gov't, P.H.S.; Article
Author(s):
Heidel, SM; MacWilliams, PS; Baird, WM; Dashwood, WM; Buters, JT; Gonzalez, FJ; Larsen, MC; Czuprynski, CJ; Jefcoate, CR
Abstract:
Humans are exposed to polycyclic aromatic hydrocarbons (PAHs) through many environmental pollutants, especially cigarette smoke. These chemicals cause a variety of tumors and immunotoxic effects, as a consequence of bioactivation by P-450 cytochromes to dihydrodiol epoxides. The recently identified cytochrome P4501B1 (CYP1B1) bioactivates PAHs but is also a physiological regulator, as evidenced by linkage of CYP1B1 deficiency to congenital human glaucoma. This investigation demonstrates that CYP...     »
Journal title abbreviation:
Cancer Res
Year:
2000
Journal volume:
60
Journal issue:
13
Pages contribution:
3454-60
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/10910056
Print-ISSN:
0008-5472
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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