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Title:

Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Article
Author(s):
Buters, JT; Sakai, S; Richter, T; Pineau, T; Alexander, DL; Savas, U; Doehmer, J; Ward, JM; Jefcoate, CR; Gonzalez, FJ
Abstract:
CYP1B1-null mice, created by targeted gene disruption in embryonic stem cells, were born at the expected frequency from heterozygous matings with no observable phenotype, thus establishing that CYP1B1 is not required for mouse development. CYP1B1 was not detectable in cultured embryonic fibroblast (EF) or in different tissues, such as lung, of the CYP1B1-null mouse treated with the aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin whereas the equivalent wild-type EF cells exp...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
1999
Journal volume:
96
Journal issue:
5
Pages contribution:
1977-82
Language:
eng
Fulltext / DOI:
doi:10.1073/pnas.96.5.1977
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/10051580
Print-ISSN:
0027-8424
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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