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Title:

Inhibitory monoclonal antibody to human cytochrome P450 2B6.

Document type:
Journal Article; Article
Author(s):
Yang, TJ; Krausz, KW; Shou, M; Yang, SK; Buters, JT; Gonzalez, FJ; Gelboin, HV
Abstract:
The human cytochrome P450 2B6 metabolizes, among numerous other substrates, diazepam, 7-ethoxycoumarin, testosterone, and phenanthrene. A recombinant baculovirus containing the human 2B6 cDNA was constructed and used to express 2B6 in Sf9 insect cells. The 2B6 was present at 1.8 +/- 0.4% of the total cellular protein and was purified to a specific content of 13.3 nmol/mg protein. Mice were immunized with the purified 2B6, and a total of 811 hybridomas were obtained from the fusion of NS-1 myelom...     »
Journal title abbreviation:
Biochem Pharmacol
Year:
1998
Journal volume:
55
Journal issue:
10
Pages contribution:
1633-40
Language:
eng
Fulltext / DOI:
doi:10.1016/s0006-2952(98)00018-5
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/9633999
Print-ISSN:
0006-2952
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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