Benutzer: Gast  Login
Mehr Felder
Einfache Suche
Titel:

Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice.

Dokumenttyp:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Article
Autor(en):
Zaher, H; Buters, JT; Ward, JM; Bruno, MK; Lucas, AM; Stern, ST; Cohen, SD; Gonzalez, FJ
Abstract:
Acetaminophen (APAP) hepatotoxicity is due to its biotransformation to a reactive metabolite, N-acetyl-p-benzoquinone imine (NAPQI), that is capable of binding to cellular macromolecules. At least two forms of cytochrome P450, CYP2E1 and CYP1A2, have been implicated in this reaction in mice. To test the combined roles of CYP1A2 and CYP2E1 in an intact animal model, a double-null mouse line lacking functional expression of CYP1A2 and CYP2E1 was produced by cross-breeding Cyp1a2-/- mice with Cyp2e...     »
Zeitschriftentitel:
Toxicol Appl Pharmacol
Jahr:
1998
Band / Volume:
152
Heft / Issue:
1
Seitenangaben Beitrag:
193-9
Sprache:
eng
Volltext / DOI:
doi:10.1006/taap.1998.8501
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/9772215
Print-ISSN:
0041-008X
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
 BibTeX