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Titel:

Differential mechanisms of cytochrome P450 inhibition and activation by alpha-naphthoflavone.

Dokumenttyp:
Journal Article; Article
Autor(en):
Koley, AP; Buters, JT; Robinson, RC; Markowitz, A; Friedman, FK
Abstract:
The anticarcinogenicity of some flavonoids has been attributed to modulation of the cytochrome P450 enzymes, which metabolize procarcinogens to their activated forms. However, the mechanism by which flavonoids inhibit some P450-mediated activities while activating others is a longstanding, intriguing question. We employed flash photolysis to measure carbon monoxide binding to P450 as a rapid kinetic technique to probe the interaction of the prototype flavonoid alpha-naphthoflavone with human cyt...     »
Zeitschriftentitel:
J Biol Chem
Jahr:
1997
Band / Volume:
272
Heft / Issue:
6
Seitenangaben Beitrag:
3149-52
Sprache:
eng
Volltext / DOI:
doi:10.1074/jbc.272.6.3149
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/9013547
Print-ISSN:
0021-9258
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
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