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Title:

Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1A1: a CO flash photolysis study.

Document type:
Journal Article; Article
Author(s):
Koley, AP; Buters, JT; Robinson, RC; Markowitz, A; Friedman, FK
Abstract:
The kinetics of CO binding to human cytochrome P450 1A1 was used to probe the interaction of polycyclic aromatic hydrocarbons (PAHs) with the membrane-bound P450 expressed in baculovirus-infected SF9 insect cells. Biexponential kinetics was observed, indicating that P450 1A1 is composed of at least two kinetically distinguishable species. To define the substrate specificity of the individual species, we evaluated the effect of a series of PAHs of varying sizes and shapes on the CO binding kineti...     »
Journal title abbreviation:
Arch Biochem Biophys
Year:
1996
Journal volume:
336
Journal issue:
2
Pages contribution:
261-7
Language:
eng
Fulltext / DOI:
doi:10.1006/abbi.1996.0556
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/8954573
Print-ISSN:
0003-9861
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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