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Title:

Specificity of cDNA-expressed human and rodent cytochrome P450s in the oxidative metabolism of the potent carcinogen 7,12-dimethylbenz[a]anthracene.

Document type:
Journal Article; Article
Author(s):
Shou, M; Korzekwa, KR; Krausz, KW; Buters, JT; Grogan, J; Goldfarb, I; Hardwick, JP; Gonzalez, FJ; Gelboin, HV
Abstract:
7,12-Dimethylbenz[a]anthracene (DMBA), a potent carcinogen, requires metabolic activation by cytochrome P450s (P450s) to electrophilic metabolites that result in DNA modification, mutagenicity, and carcinogenicity. In this study, we used eight human forms, four rodent forms, and one rabbit form of P450 expressed from recombinant vaccinia or baculovirus vectors to define their specificity for metabolizing DMBA. Of the eight human P450s, 1A1 was the most active (specific activity = 14.7 nmol/min/n...     »
Journal title abbreviation:
Mol Carcinog
Year:
1996
Journal volume:
17
Journal issue:
4
Pages contribution:
241-9
Language:
eng
Fulltext / DOI:
doi:10.1002/(SICI)1098-2744(199612)17:4<241::AID-MC8>3.0.CO;2-G
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/8989918
Print-ISSN:
0899-1987
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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