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Titel:

Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Article
Autor(en):
Bourdi, M; Chen, W; Peter, RM; Martin, JL; Buters, JT; Nelson, SD; Pohl, LR
Abstract:
Autoantibodies against specific human cytochrome P450s have been found in the sera of patients suffering from a variety of diseases, including those caused by drugs. In the cases of tienilic acid- and dihydralazine-induced hepatitis, patients have serum autoantibodies directed against cytochromes P450 2C9 and P450 1A2, respectively. In the present study, we have found that 25 of 56 (45%) patients diagnosed with halothane hepatitis have autoantibodies that react with human cytochrome P450 2E1 tha...     »
Zeitschriftentitel:
Chem Res Toxicol
Jahr:
1996
Band / Volume:
9
Heft / Issue:
7
Seitenangaben Beitrag:
1159-66
Sprache:
eng
Volltext / DOI:
doi:10.1021/tx960083q
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/8902272
Print-ISSN:
0893-228X
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
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