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Titel:

Role of CYP2E1 in the hepatotoxicity of acetaminophen.

Dokumenttyp:
Journal Article; Article
Autor(en):
Lee, SS; Buters, JT; Pineau, T; Fernandez-Salguero, P; Gonzalez, FJ
Abstract:
CYP2El, a cytochrome P-450 that is well conserved across mammalian species, metabolizes ethanol and many low molecular weight toxins and cancer suspect agents. The cyp2e1 gene was isolated, and a mouse line that lacks expression of CYP2E1 was generated by homologous recombination in embryonic stem cells. Animals deficient in expression of the enzyme were fertile, developed normally, and exhibited no obvious phenotypic abnormalities, thus indicating that CYP2E1 has no critical role in mammalian d...     »
Zeitschriftentitel:
J Biol Chem
Jahr:
1996
Band / Volume:
271
Heft / Issue:
20
Seitenangaben Beitrag:
12063-7
Sprache:
eng
Volltext / DOI:
doi:10.1074/jbc.271.20.12063
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/8662637
Print-ISSN:
0021-9258
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
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