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Title:

Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Kuroda, R; Usas, A; Kubo, S; Corsi, K; Peng, H; Rose, T; Cummins, J; Fu, FH; Huard, J
Abstract:
OBJECTIVE: Muscle-derived stem cells (MDSCs) isolated from mouse skeletal muscle exhibit long-time proliferation, high self-renewal, and multipotent differentiation. This study was undertaken to investigate the ability of MDSCs that were retrovirally transduced to express bone morphogenetic protein 4 (BMP-4) to differentiate into chondrocytes in vitro and in vivo and enhance articular cartilage repair. METHODS: Using monolayer and micromass pellet culture systems, we evaluated the in vitro chond...     »
Journal title abbreviation:
Arthritis Rheum
Year:
2006
Journal volume:
54
Journal issue:
2
Pages contribution:
433-42
Language:
eng
Fulltext / DOI:
doi:10.1002/art.21632
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16447218
Print-ISSN:
0004-3591
TUM Institution:
Fachgebiet Sportorthopädie (Prof. Imhoff)
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