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Title:

Leptin promotes vascular remodeling and neointimal growth in mice.

Document type:
Journal Article; Article
Author(s):
Schäfer, K; Halle, M; Goeschen, C; Dellas, C; Pynn, M; Loskutoff, DJ; Konstantinides, S
Abstract:
OBJECTIVE: Human obesity is associated with elevated leptin levels and a high risk of death from cardiovascular disease. In the present study, we investigated the effects of leptin on vascular wound healing and arterial lesion growth in mice. METHODS AND RESULTS: Wild-type mice placed on an atherogenic, high-fat diet had elevated (9-fold) leptin levels compared with their counterparts maintained on normal chow, and the former demonstrated significantly enhanced neointimal thickening after caroti...     »
Journal title abbreviation:
Arterioscler Thromb Vasc Biol
Year:
2004
Journal volume:
24
Journal issue:
1
Pages contribution:
112-7
Language:
eng
Fulltext / DOI:
doi:10.1161/01.ATV.0000105904.02142.e7
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/14615386
Print-ISSN:
1079-5642
TUM Institution:
Poliklinik für Präventive und Rehabilitative Sportmedizin
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