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Title:

Shear stress insensitivity of endothelial nitric oxide synthase expression as a genetic risk factor for coronary heart disease.

Document type:
Journal Article; Article
Author(s):
Cattaruzza, M; Guzik, TJ; S?odowski, W; Pelvan, A; Becker, J; Halle, M; Buchwald, AB; Channon, KM; Hecker, M
Abstract:
Coronary heart disease (CHD) is based on the development of atherosclerosis in coronary arteries. Shear stress-induced endothelial nitric oxide (NO) release not only contributes to local blood pressure control but also effectively helps to retard atherosclerosis. Therefore, functionally relevant polymorphisms in the endothelial NO synthase (NOS-3) gene may contribute to the development of CHD. NOS-3 expression was analyzed in endothelial cells isolated from umbilical cords genotyped for the -786...     »
Journal title abbreviation:
Circ Res
Year:
2004
Journal volume:
95
Journal issue:
8
Pages contribution:
841-7
Language:
eng
Fulltext / DOI:
doi:10.1161/01.RES.0000145359.47708.2f
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15375006
Print-ISSN:
0009-7330
TUM Institution:
Poliklinik für Präventive und Rehabilitative Sportmedizin
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