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Titel:

Receptor-dependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11.

Dokumenttyp:
Journal Article; Article
Autor(en):
Vogt, S; Grosse, R; Schultz, G; Offermanns, S
Abstract:
The small GTPase RhoA is involved in the regulation of various cellular functions like the remodeling of the actin cytoskeleton and the induction of transcriptional activity. G-protein-coupled receptors (GPCRs), which are able to activate Gq/G11 and G12/G13 are major upstream regulators of RhoA activity, and G12/G13 have been shown to couple GPCRs to the activation of Rho by regulating the activity of a subfamily of RhoGEF proteins. However, the possible contribution of Gq/G11 to the regulation...     »
Zeitschriftentitel:
J Biol Chem
Jahr:
2003
Band / Volume:
278
Heft / Issue:
31
Seitenangaben Beitrag:
28743-9
Sprache:
eng
Volltext / DOI:
doi:10.1074/jbc.M304570200
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12771155
Print-ISSN:
0021-9258
TUM Einrichtung:
Fachgebiet Sportorthopädie (Prof. Imhoff)
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