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Title:

Iron oxide particles for molecular magnetic resonance imaging cause transient oxidative stress in rat macrophages.

Document type:
Journal Article; Article
Author(s):
Stroh, A; Zimmer, C; Gutzeit, C; Jakstadt, M; Marschinke, F; Jung, T; Pilgrimm, H; Grune, T
Abstract:
Iron oxide particles are a promising marker in molecular magnetic resonance imaging. They are used to label distinct cell populations either in vitro or in vivo. We investigated for the first time whether small citrate-coated very small superparamagnetic iron oxide particles (VSOPs) can lead to an increase in cellular oxidative stress. We incubated rat macrophages (RAW) in vitro with iron oxide particles. We observed a massive uptake of VSOPs measured both with atomic absorption spectroscopy and...     »
Journal title abbreviation:
Free Radic Biol Med
Year:
2004
Journal volume:
36
Journal issue:
8
Pages contribution:
976-84
Language:
eng
Fulltext / DOI:
doi:10.1016/j.freeradbiomed.2004.01.016
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15059638
Print-ISSN:
0891-5849
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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