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Title:

The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells.

Document type:
Journal Article; Article
Author(s):
Auernhammer, CJ; Dorn, F; Vlotides, G; Hengge, S; Kopp, FB; Spoettl, G; Cengic, N; Engelhardt, D; Weber, MM
Abstract:
The effects of murine oncostatin M (mOSM) are specifically mediated by the heterodimeric oncostatin M receptor (OSMR)/gp130 receptor complex. In the current study we demonstrate that murine adrenocortical Y-1 tumor cells express the OSMR/gp130 complex. Incubation of Y-1 cells with 1 and 10 ng/ml mOSM induces cell death due to specific induction of apoptosis. Western blot analysis of Y-1 cells incubated with mOSM for 24 h revealed caspase-3 cleavage and poly(ADP-ribase) polymerase (PARP) cleavage...     »
Journal title abbreviation:
J Endocrinol
Year:
2004
Journal volume:
180
Journal issue:
3
Pages contribution:
479-86
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15012602
Print-ISSN:
0022-0795
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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