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Title:

Comparative study of gp130 cytokine effects on corticotroph AtT-20 cells--redundancy or specificity of neuroimmunoendocrine modulators?

Document type:
Journal Article; Article
Author(s):
Auernhammer, CJ; Kopp, FB; Vlotides, G; Dorn, F; Isele, NB; Spöttl, G; Cengic, N; Weber, MM; Senaldi, G; Engelhardt, D
Abstract:
OBJECTIVE: This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. METHODS: Cytokines were tested at equimolar concentrations from 0.078 to 10 nM. Tyrosine phosphorylation of the signal transducer and activator of transcription (STAT)3 and STAT1, the STAT-dependent suppressor of cytokine signaling (SOCS)-3 promoter activity, SOCS-3 gene expression, STAT-dependent POMC promoter activity and adrenocorticotropic hormone (ACTH) s...     »
Journal title abbreviation:
Neuroimmunomodulation
Year:
2004
Journal volume:
11
Journal issue:
4
Pages contribution:
224-32
Language:
eng
Fulltext / DOI:
doi:10.1159/000078440
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15249728
Print-ISSN:
1021-7401
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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