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Titel:

Noise enhanced hormonal signal transduction through intracellular calcium oscillations.

Dokumenttyp:
Journal Article; Article
Autor(en):
Läer, L; Kloppstech, M; Schöfl, C; Sejnowski, TJ; Brabant, G; Prank, K
Abstract:
In a wide range of non-linear dynamical systems, noise may enhance the detection of weak deterministic input signals. Here, we demonstrate this phenomenon for transmembrane signaling in a hormonal model system of intracellular Ca(2+) oscillations. Adding Gaussian noise to a subthreshold extracellular pulsatile stimulus increased the sensitivity in the dose-response relation of the Ca(2+) oscillations compared to the same noise signal added as a constant mean level. These findings may have import...     »
Zeitschriftentitel:
Biophys Chem
Jahr:
2001
Band / Volume:
91
Heft / Issue:
2
Seitenangaben Beitrag:
157-66
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/11429205
Print-ISSN:
0301-4622
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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