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Title:

Tumor cell endocytosis imaging facilitates delineation of the glioma-brain interface.

Document type:
Journal Article; Article
Author(s):
Zimmer, C; Wright, SC; Engelhardt, RT; Johnson, GA; Kramm, C; Breakefield, XO; Weissleder, R
Abstract:
We describe a method for measuring tumor cell endocytosis in vivo and provide the anatomic correlate of this tumor cell function using a superparamagnetic and histologically detectable marker for cell uptake (MION). Rats (n = 22) were intrahemispherically implanted with a thymidine kinase (TK)-positive 9L gliosarcoma cell line, where TK served as the tumor marker. Twenty-four hours after intravenous injection of 10 mg Fe/kg of MION, rat brains were removed and underwent MR imaging ex vivo at nea...     »
Journal title abbreviation:
Exp Neurol
Year:
1997
Journal volume:
143
Journal issue:
1
Pages contribution:
61-9
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/9000446
Print-ISSN:
0014-4886
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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