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Titel:

Selective uptake of viral and monocrystalline particles delivered intra-arterially to experimental brain neoplasms.

Dokumenttyp:
Journal Article; Article
Autor(en):
Rainov, NG; Zimmer, C; Chase, M; Kramm, CM; Chiocca, EA; Weissleder, R; Breakefield, XO
Abstract:
In this study we investigated the intra-arterial delivery of viral and nonviral particles to experimental brain tumors. A herpes simplex virus (HSV) vector and monocrystalline iron oxide nanoparticles (MION) were injected into the internal carotid artery of Fisher 344 rats harboring intracerebral 9L gliosarcomas, using bradykinin to disrupt the blood-tumor barrier. Brain and internal organs were stained both for virus-mediated gene expression and for iron. Quantitative comparisons of gene expres...     »
Zeitschriftentitel:
Hum Gene Ther
Jahr:
1995
Band / Volume:
6
Heft / Issue:
12
Seitenangaben Beitrag:
1543-52
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/8664379
Print-ISSN:
1043-0342
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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