User: Guest  Login
Title:

Functional and molecular characterization of interleukin-2 transgenic Ewing tumor cells for in vivo immunotherapy.

Document type:
Evaluation Studies; Journal Article; Article
Author(s):
Staege, MS; Hansen, G; Baersch, G; Burdach, S
Abstract:
BACKGROUND: Interleukin-2 (IL-2) is a potent cytokine with potential activity against several tumors including Ewing tumors (ET). Side effects of systemic IL-2 can be circumvented by the use of transgenic tumor cells. However, in vitro manipulation may change the overall gene expression profile of tumor cells unfavorably. Therefore, we assessed gene expression profiles, safety, and immunomodulatory efficacy of IL-2 transgenic (IL-2-tg) ET cells in vitro and in NOD/scid mice. PROCEDURE: Viable wi...     »
Journal title abbreviation:
Pediatr Blood Cancer
Year:
2004
Journal volume:
43
Journal issue:
1
Pages contribution:
23-34
Language:
eng
Fulltext / DOI:
doi:10.1002/pbc.20013
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15170886
Print-ISSN:
1545-5009
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
 BibTeX