Diagnosing asthma in general practice with portable exhaled nitric oxide measurement--results of a prospective diagnostic study: FENO < or = 16 ppb better than FENO < or =12 ppb to rule out mild and moderate to severe asthma [added].

Schneider, A; Tilemann, L; Schermer, T; Gindner, L; Laux, G; Szecsenyi, J; Meyer, FJ

doi:10.1186/1465-9921-10-15

2009

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Title:: Diagnosing asthma in general practice with portable exhaled nitric oxide measurement--results of a prospective diagnostic study: FENO < or = 16 ppb better than FENO < or =12 ppb to rule out mild and moderate to severe asthma [added].
Document type:: Evaluation Studies; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Correction
Author(s):: Schneider, A; Tilemann, L; Schermer, T; Gindner, L; Laux, G; Szecsenyi, J; Meyer, FJ
Abstract:: To evaluate the sensitivity, specificity and predictive values of fractional exhaled nitric oxide (FENO) for the diagnosis of asthma in general practice.Prospective diagnostic study with 160 patients attending 10 general practices for the first time with complaints suspicious of obstructive airway disease (OAD). Patients were referred to a lung function laboratory for diagnostic investigation. The index test was FENO measured with a portable FENO analyser based on electrochemical sensor. The reference standard was the Tiffeneau ratio (FEV1/VC) as received by spirometric manoeuvre and/or results of bronchial provocation. Bronchial provocation with methacholine was performed to determine bronchial hyper-responsiveness (BHR) in the event of inconclusive spirometric results.88 (55%) were female; their average age was 43.9 years. 75 (46.9%) patients had asthma, 25 (15.6%) had COPD, 8 (5.0%) had an overlap of COPD and asthma, and 52 (32.5%) had no OAD. At a cut-off level of 46 parts per billion (ppb) (n = 30; 18.8%), sensitivity was 32% (95%CI 23-43%), specificity 93% (95%CI 85-97%), positive predictive value (PPV) 80% (95%CI 63-91%), negative predictive value (NPV) 61% (95%CI 52-69%) when compared with a 20% fall in FEV1 from the baseline value (PC20) after inhaling methacholine concentration 46 ppb. Mild and moderate to severe asthma could be ruled out with FENO
Journal title abbreviation:: Respir Res
Year:: 2009
Journal volume:: 10
Pages contribution:: 15
Language:: eng
Fulltext / DOI:: doi:10.1186/1465-9921-10-15
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/19254389
Print-ISSN:: 1465-9921
TUM Institution:: Lehrstuhl für Allgemeinmedizin (Prof. Schneider) (keine SAP-Zuordnung!)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für Allgemeinmedizin und Versorgungsforschung (Prof. Schneider)Lehrstuhl für Allgemeinmedizin (Prof. Schneider)2009

mediaTUM Gesamtbestand Hochschulbibliographie 2009 Fakultäten Medizin Institut für Allgemeinmedizin (keine SAP-Zuordnung!)