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Titel:

Point mutations in or near the antigen-binding groove of HLA-DR3 implicate class II-associated invariant chain peptide affinity as a constraint on MHC class II polymorphism.

Dokumenttyp:
Journal Article
Autor(en):
Doebele, RC; Pashine, A; Liu, W; Zaller, DM; Belmares, M; Busch, R; Mellins, ED
Abstract:
During maturation of MHC II molecules, newly synthesized and assembled complexes of MHC II alphabeta dimers with invariant chain (Ii) are targeted to endosomes, where Ii is proteolyzed, leaving remnant class II-associated Ii peptides (CLIP) in the MHC II peptide binding groove. CLIP must be released, usually with assistance from the endosomal MHC II peptide exchange factor, HLA-DM, before MHC II molecules can bind endosomal peptides. Structural factors that control rates of CLIP release remain p...     »
Zeitschriftentitel:
J Immunol
Jahr:
2003
Band / Volume:
170
Heft / Issue:
9
Seitenangaben Beitrag:
4683-92
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12707347
Print-ISSN:
0022-1767
TUM Einrichtung:
Institut für Medizinische Statistik und Epidemiologie
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