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Title:

[3H]-nociceptin ligand-binding and nociceptin opioid receptor mrna expression in the human brain.

Document type:
Journal Article; Article
Author(s):
Berthele, A; Platzer, S; Dworzak, D; Schadrack, J; Mahal, B; Büttner, A; Assmus, HP; Wurster, K; Zieglgänsberger, W; Conrad, B; Tölle, TR
Abstract:
Following the cloning of the novel nociceptin opioid receptor (NOP(1)) and the identification of its endogenous ligand orphanin FQ/nociceptin the distribution and functional role of the NOP(1) receptor system have been studied mainly in the rodent CNS. In the present study the regional distribution and splice variant expression of the NOP(1) receptor was investigated in the adult human brain using [(3)H]-nociceptin autoradiography, NOP(1) reverse transcriptase PCR and mRNA in situ hybridization....     »
Journal title abbreviation:
Neuroscience
Year:
2003
Journal volume:
121
Journal issue:
3
Pages contribution:
629-40
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/14568023
Print-ISSN:
0306-4522
TUM Institution:
Neurologische Klinik und Poliklinik
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