Galantamine demonstrates efficacy and safety in elderly patients with Alzheimer disease.

Marcusson, J; Bullock, R; Gauthier, S; Kurz, A; Schwalen, S

2003

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Titel:: Galantamine demonstrates efficacy and safety in elderly patients with Alzheimer disease.
Dokumenttyp:: Journal Article; Proceedings Paper
Autor(en):: Marcusson, J; Bullock, R; Gauthier, S; Kurz, A; Schwalen, S
Abstract:: Alzheimer disease (AD) treatment guidelines state that cholinergic agents are not cost-effective in patients with more severe disease. Because many physicians may deem an older patient unlikely to respond to treatment, older AD patients may remain untreated. Galantamine (Reminyl), a novel cholinergic agent, is effective in mild to moderate AD. This post hoc analysis of pooled phase III galantamine clinical trials was designed to assess whether older (> or =80 years) and younger (< or =79 years) AD patients experience similar benefits with galantamine based on changes in the ADAS-cog and CIBIC-plus. Mean ADAS-cog scores for older patients treated with galantamine 24 mg/day significantly improved versus baseline and versus placebo at month 3. Cognitive improvement was maintained versus placebo at month 6; the ADAS-cog score for placebo patients dropped below baseline at month 6. Change in CIBIC-plus for galantamine was significantly different from placebo at months 5 to 6. Mean ADAS-cog score in older patients taking galantamine for 12 months remained above baseline. The score for patients taking placebo for 6 months before switching to galantamine did not differ significantly from baseline at 12 months but was lower than in patients receiving galantamine for 12 months. Incidence of adverse events in patients > 80 years was similar to that in the overall study population. Galantamine maintained cognitive and global function in patients > 80 years with mild to moderate AD for at least 5 to 6 months and cognitive efficacy for 12 months. Prescribing approved therapies such as galantamine for older patients with AD is recommended.
Zeitschriftentitel:: Alzheimer Dis Assoc Disord
Jahr:: 2003
Band / Volume:: 17 Suppl 3
Seitenangaben Beitrag:: S86-91
Sprache:: eng
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/14512822
Print-ISSN:: 0893-0341
TUM Einrichtung:: Klinik und Poliklinik für Psychiatrie und Psychotherapie
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Psychiatrie und Psychotherapie (Prof. Priller)2003