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Title:

NC2 alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein

Document type:
Journal Article; Article
Author(s):
Klejman, MP; Pereira, LA; van Zeeburg, HJT; Gilfillan, S; Meisterernst, M; Timmers, HTM
Abstract:
Transcriptional activity of the TATA-binding protein (TBP) is controlled by a variety of proteins. The BTAF1 protein (formerly known as TAF(II)170/TAF-172 and the human ortholog of Saccharomyces cerevisiae Mot1p) and the NC2 complex composed of NC2alpha (DRAPI) and NC2beta (Dr1) are able to bind to TBP directly and regulate RNA polymerase II transcription both positively and negatively. Here, we present evidence that the NC2alpha subunit interacts with BTAF1. In contrast, the NC2beta subunit is...     »
Journal title abbreviation:
Mol Cell Biol
Year:
2004
Journal volume:
24
Journal issue:
22
Pages contribution:
10072-10082
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15509807
Print-ISSN:
0270-7306
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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