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Title:

Epstein-Barr virus vector-mediated gene transfer into human B cells: potential for antitumor vaccination.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Hellebrand, E; Mautner, J; Reisbach, G; Nimmerjahn, F; Hallek, M; Mocikat, R; Hammerschmidt, W
Abstract:
The efficient gene transfer of immunostimulatory cytokines into autologous tumor cells or the transfer of tumor-associated antigens into professional antigen-presenting cells is a prerequisite for many immunotherapeutic approaches. In particular with B cells, the efficiency of gene uptake is one of the limiting factors in cell-based vaccine strategies, since normal and malignant human B cells are commonly refractory to transducing gene vectors. Due to its natural tropism for human B cells, Epste...     »
Journal title abbreviation:
Gene Ther
Year:
2006
Journal volume:
13
Journal issue:
2
Pages contribution:
150-62
Language:
eng
Fulltext / DOI:
doi:10.1038/sj.gt.3302602
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16136164
Print-ISSN:
0969-7128
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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