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Title:

Verification of predicted alternatively spliced Wnt genes reveals two new splice variants (CTNNB1 and LRP5) and altered Axin-1 expression during tumour progression.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Pospisil, H; Herrmann, A; Butherus, K; Pirson, S; Reich, JG; Kemmner, W
Abstract:
BACKGROUND: Splicing processes might play a major role in carcinogenesis and tumour progression. The Wnt pathway is of crucial relevance for cancer progression. Therefore we focussed on the Wnt/beta-catenin signalling pathway in order to validate the expression of sequences predicted as alternatively spliced by bioinformatic methods. Splice variants of its key molecules were selected, which may be critical components for the understanding of colorectal tumour progression and may have the potenti...     »
Journal title abbreviation:
BMC Genomics
Year:
2006
Journal volume:
7
Pages contribution:
148
Language:
eng
Fulltext / DOI:
doi:10.1186/1471-2164-7-148
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16772034
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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