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Titel:

Epstein-Barr virus vector-mediated gene transfer into human B cells: potential for antitumor vaccination.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Hellebrand, E; Mautner, J; Reisbach, G; Nimmerjahn, F; Hallek, M; Mocikat, R; Hammerschmidt, W
Abstract:
The efficient gene transfer of immunostimulatory cytokines into autologous tumor cells or the transfer of tumor-associated antigens into professional antigen-presenting cells is a prerequisite for many immunotherapeutic approaches. In particular with B cells, the efficiency of gene uptake is one of the limiting factors in cell-based vaccine strategies, since normal and malignant human B cells are commonly refractory to transducing gene vectors. Due to its natural tropism for human B cells, Epste...     »
Zeitschriftentitel:
Gene Ther
Jahr:
2006
Band / Volume:
13
Heft / Issue:
2
Seitenangaben Beitrag:
150-62
Sprache:
eng
Volltext / DOI:
doi:10.1038/sj.gt.3302602
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16136164
Print-ISSN:
0969-7128
TUM Einrichtung:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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