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Title:

Intra- and interindividual epigenetic variation in human germ cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Flanagan, JM; Popendikyte, V; Pozdniakovaite, N; Sobolev, M; Assadzadeh, A; Schumacher, A; Zangeneh, M; Lau, L; Virtanen, C; Wang, SC; Petronis, A
Abstract:
Epigenetics represents a secondary inheritance system that has been poorly investigated in human biology. The objective of this study was to perform a comprehensive analysis of DNA methylation variation between and within the germlines of normal males. First, methylated cytosines were mapped using bisulphite modification-based sequencing in the promoter regions of the following disease genes: presenilins (PSEN1 and PSEN2), breast cancer (BRCA1 and BRCA2), myotonic dystrophy (DM1), and Huntington...     »
Journal title abbreviation:
Am J Hum Genet
Year:
2006
Journal volume:
79
Journal issue:
1
Pages contribution:
67-84
Language:
eng
Fulltext / DOI:
doi:10.1086/504729
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16773567
Print-ISSN:
0002-9297
TUM Institution:
Klinik und Poliklinik für Psychiatrie und Psychotherapie
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