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Titel:

Microarray-based DNA methylation profiling: technology and applications.

Dokumenttyp:
Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Schumacher, A; Kapranov, P; Kaminsky, Z; Flanagan, J; Assadzadeh, A; Yau, P; Virtanen, C; Winegarden, N; Cheng, J; Gingeras, T; Petronis, A
Abstract:
This work is dedicated to the development of a technology for unbiased, high-throughput DNA methylation profiling of large genomic regions. In this method, unmethylated and methylated DNA fractions are enriched using a series of treatments with methylation sensitive restriction enzymes, and interrogated on microarrays. We have investigated various aspects of the technology including its replicability, informativeness, sensitivity and optimal PCR conditions using microarrays containing oligonucle...     »
Zeitschriftentitel:
Nucleic Acids Res
Jahr:
2006
Band / Volume:
34
Heft / Issue:
2
Seitenangaben Beitrag:
528-42
Sprache:
eng
Volltext / DOI:
doi:10.1093/nar/gkj461
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16428248
Print-ISSN:
0305-1048
TUM Einrichtung:
Klinik und Poliklinik für Psychiatrie und Psychotherapie
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