Strong genetic evidence for association of TOR1A/TOR1B with idiopathic dystonia.

Dokumenttyp:: Journal Article; Research Support, Non-U.S. Gov't
Autor(en):: Kamm, C; Asmus, F; Mueller, J; Mayer, P; Sharma, M; Muller, UJ; Beckert, S; Ehling, R; Illig, T; Wichmann, HE; Poewe, W; Mueller, JC; Gasser, T
Titel:: Strong genetic evidence for association of TOR1A/TOR1B with idiopathic dystonia.
Abstract:: Recently, association of a TOR1A(DYT1)/TOR1B risk haplotype with common forms of idiopathic dystonia has been reported in the Icelandic population. Here we report a strong association of two single nucleotide polymorphisms within or in close proximity to the TOR1A 3'UTR, with the lowest p value being 0.000008, in a larger cohort of German and Austrian patients with predominantly focal sporadic dystonia.
Zeitschriftentitel:: Neurology
Jahr:: 2006
Band / Volume:: 67
Heft / Issue:: 10
Seitenangaben Beitrag:: 1857-9
Sprache:: eng
Volltext / DOI:: doi:10.1212/01.wnl.0000244423.63406.17
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/17130424
Print-ISSN:: 0028-3878
TUM Einrichtung:: Klinik und Poliklinik für Psychiatrie und Psychotherapie
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