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Title:

Possible gender-dependent association of vascular endothelial growth factor (VEGF) gene and ALS.

Document type:
Controlled Clinical Trial; Journal Article
Author(s):
Fernández-Santiago, R; Sharma, M; Mueller, JC; Gohlke, H; Illig, T; Anneser, J; Münch, C; Ludolph, A; Kamm, C; Gasser, T
Abstract:
Individuals homozygous for haplotypes -2578-A/-1154-A/-634-G or -2578-A/-1154-G/-634-G in the promoter/5'UTR of the VEGF gene have a 1.8-fold increased risk of ALS in several European populations. We did not observe any significant association with single markers, or haplotype pairs, in a German sample of 580 sporadic ALS patients and 628 controls. However, the promoter SNP-1154 (rs1570360) was associated with affection status in women (p = 0.036), suggesting that the VEGF effect may be dependen...     »
Journal title abbreviation:
Neurology
Year:
2006
Journal volume:
66
Journal issue:
12
Pages contribution:
1929-31
Language:
eng
Fulltext / DOI:
doi:10.1212/01.wnl.0000219756.71928.25
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16801663
Print-ISSN:
0028-3878
TUM Institution:
Klinik und Poliklinik für Psychiatrie und Psychotherapie
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