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Title:

A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease.

Document type:
Journal Article; Article
Author(s):
Riemenschneider, M; Konta, L; Friedrich, P; Schwarz, S; Taddei, K; Neff, F; Padovani, A; Kölsch, H; Laws, SM; Klopp, N; Bickeböller, H; Wagenpfeil, S; Mueller, JC; Rosenberger, A; Diehl-Schmid, J; Archetti, S; Lautenschlager, N; Borroni, B; Müller, U; Illig, T; Heun, R; Egensperger, R; Schlegel, J; Förstl, H; Martins, RN; Kurz, A
Abstract:
A number of susceptibility loci for Alzheimer's disease (AD) have been identified including a region on Chromosome 10q21-q22. Within this region the plasminogen activator urokinase gene (PLAU) was considered as a reasonable candidate from its functional implication in plasmin generation, a serine protease capable of degrading beta-Amyloid (Abeta) protein. We screened 56 single nucleotide polymorphisms (SNPs) around PLAU using 1751 individuals from four independent case-control samples (Munich, N...     »
Journal title abbreviation:
Hum Mol Genet
Year:
2006
Journal volume:
15
Journal issue:
16
Pages contribution:
2446-56
Language:
eng
Fulltext / DOI:
doi:10.1093/hmg/ddl167
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16825285
Print-ISSN:
0964-6906
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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