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Titel:

The sepiapterin reductase gene region reveals association in the PARK3 locus: analysis of familial and sporadic Parkinson's disease in European populations.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Sharma, M; Mueller, JC; Zimprich, A; Lichtner, P; Hofer, A; Leitner, P; Maass, S; Berg, D; Dürr, A; Bonifati, V; De michele, G; Oostra, B; Brice, A; Wood, NW; Müller-Myhsok, B; Gasser, T
Abstract:
BACKGROUND: Parkinson's disease is a genetically complex disease with mixed mode of inheritance. Recently, a haplotype across the sepiapterin reductase (SPR) gene, which is located in the PARK3 linkage region, was shown to modulate age of onset of Parkinson's disease in sibships from North America. OBJECTIVE: To make a thorough assessment of the SPR gene region in sporadic Parkinson's disease. METHODS: A linkage study in 122 European sibship families with five microsatellite and 17 single nucleo...     »
Zeitschriftentitel:
J Med Genet
Jahr:
2006
Band / Volume:
43
Heft / Issue:
7
Seitenangaben Beitrag:
557-62
Sprache:
eng
Volltext / DOI:
doi:10.1136/jmg.2005.039149
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16443856
Print-ISSN:
0022-2593
TUM Einrichtung:
Klinik und Poliklinik für Psychiatrie und Psychotherapie
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