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- Document type:
- Journal Article; Research Support, Non-U.S. Gov't; Article
- Author(s):
- Diehl-Schmid, J; Grimmer, T; Drzezga, A; Bornschein, S; Perneczky, R; Förstl, H; Schwaiger, M; Kurz, A
- Title:
- Longitudinal changes of cerebral glucose metabolism in semantic dementia.
- Abstract:
- BACKGROUND: Semantic dementia (SD). Objective: To identify the pattern of decline of cerebral glucose metabolism in SD using cerebral (18)F-fluoro-2-desoxy-D-glucose positron emission tomography scanning ((18)F-FDG-PET). METHODS: Eight patients with SD underwent (18)F-FDG-PET at baseline and at re-examination in average 15 months later. RESULTS: Compared with healthy control subjects, patients with SD showed a significant asymmetrical (left > right) hypometabolism of the temporal lobes, particularly of the anterior poles, at baseline. At follow-up, we observed a deterioration of cognitive abilities. However, in addition to the temporal lobes no other cortical or subcortical region showed a significant reduction of glucose metabolism except the anterior cingulate cortex (pcorr < 0.05). CONCLUSION: Subtle functional changes suffice to produce significant neuropsycho- logical deterioration.
- Journal title abbreviation:
- Dement Geriatr Cogn Disord
- Year:
- 2006
- Journal volume:
- 22
- Journal issue:
- 4
- Pages contribution:
- 346-51
- Language:
- eng
- Fulltext / DOI:
- doi:10.1159/000095624
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/16954690
- Print-ISSN:
- 1420-8008
- TUM Institution:
- Klinik und Poliklinik für Nuklearmedizin; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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