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- Titel:
Prognostic value of N-terminal pro-brain natriuretic peptide in patients with chronic stable angina.
- Dokumenttyp:
- Journal Article; Article
- Autor(en):
- Ndrepepa, G; Braun, S; Niemöller, K; Mehilli, J; von Beckerath, N; von Beckerath, O; Vogt, W; Schömig, A; Kastrati, A
- Abstract:
- BACKGROUND: Patients with chronic stable angina are poorly characterized in terms of biomarkers that help in the assessment of prognosis. We investigated whether plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) may be used as a prognostic marker in patients with chronic stable angina treated with coronary stenting. METHODS AND RESULTS: Plasma levels of NT-proBNP were measured in 1059 patients with chronic stable angina and coronary angiographic confirmation of significant coronary artery disease. The primary end point of the study was mortality. After a median of 3.6 years (interquartile range, 3.3 to 4.5 years), there were 106 deaths. Kaplan-Meier estimates of 5-year mortality were 4.7% in the first quartile, 7.8% in the second quartile, 11.4% in the third quartile, and 32.7% in the fourth quartile of NT-proBNP (P<0.001). A Cox proportional hazards model showed that NT-proBNP was the strongest correlate of mortality (adjusted hazards ratio [HR], 5.83 [95% confidence interval: 2.07 to 16.44] for the fourth versus the first quartile). A similar prognostic value of NT-proBNP was demonstrated for cardiovascular mortality (HR, 5.98 [1.55 to 23.13] for the fourth versus the first quartile) and for patients with New York Heart Association class I and II (HR, 6.03 [2.07 to 17.52] for the fourth versus the first quartile). CONCLUSIONS: Circulating levels of NT-proBNP are a strong prognostic biomarker for patients with chronic stable angina.
- Zeitschriftentitel:
- Circulation
- Jahr:
- 2005
- Band / Volume:
- 112
- Heft / Issue:
- 14
- Seitenangaben Beitrag:
- 2102-7
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1161/CIRCULATIONAHA.105.550715
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/16186420
- Print-ISSN:
- 0009-7322
- TUM Einrichtung:
- I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!)
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