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- Document type:
- Clinical Trial; Journal Article; Randomized Controlled Trial; Article
- Author(s):
- Massberg, S; Mueller, I; Besta, F; Thomas, P; Gawaz, M
- Title:
- Effects of 2 different antiplatelet regimens with abciximab or tirofiban on platelet function in patients undergoing coronary stenting.
- Abstract:
- BACKGROUND: We sought to compare the antiplatelet effects of the glycoprotein IIb-IIIa receptor blockers abciximab or tirofiban, combined with an adjuvant therapy with clopidogrel and aspirin. STUDY DESIGN AND METHODS: Twenty patients undergoing coronary stenting were randomly assigned to receive either abciximab or tirofiban combined with aspirin and clopidogrel. Serial blood samples were taken to assess platelet aggregation, P-selectin expression, thrombin generation, and platelet-induced endothelial cell expression of MCP-1, uPAR, and ICAM-1.Results and conclusions The therapy with aspirin plus clopidogrel attenuated agonist-induced platelet aggregation and P-selectin surface exposure (P <.05 vs aspirin monotherapy). Both tirofiban and abciximab further reduced agonist-induced platelet aggregation (P <.05), and decreased thrombin generation but had no effect on platelet alpha-granule release. None of the antithrombotic strategies significantly affected platelet-induced endothelial cell activation. Since platelet adhesion/degranulation initiates an inflammatory/mitogenic response in the vascular wall, future therapeutic strategies will have to be aimed at the inhibition of platelet release reactions.
- Journal title abbreviation:
- Am Heart J
- Year:
- 2003
- Journal volume:
- 146
- Journal issue:
- 5
- Pages contribution:
- E19
- Language:
- eng
- Fulltext / DOI:
- doi:10.1016/S0002-8703(03)00368-5
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/14597948
- Print-ISSN:
- 0002-8703
- TUM Institution:
- I. Medizinische Klinik und Poliklinik (Kardiologie)
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