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Titel:

G13 is an essential mediator of platelet activation in hemostasis and thrombosis.

Dokumenttyp:
Journal Article; Article
Autor(en):
Moers, A; Nieswandt, B; Massberg, S; Wettschureck, N; Grüner, S; Konrad, I; Schulte, V; Aktas, B; Gratacap, MP; Simon, MI; Gawaz, M; Offermanns, S
Abstract:
Platelet activation at sites of vascular injury is essential for primary hemostasis, but also underlies arterial thrombosis leading to myocardial infarction or stroke. Platelet activators such as adenosine diphosphate, thrombin or thromboxane A(2) (TXA(2)) activate receptors that are coupled to heterotrimeric G proteins. Activation of platelets through these receptors involves signaling through G(q), G(i) and G(z) (refs. 4-6). However, the role and relative importance of G(12) and G(13), which a...     »
Zeitschriftentitel:
Nat Med
Jahr:
2003
Band / Volume:
9
Heft / Issue:
11
Seitenangaben Beitrag:
1418-22
Sprache:
eng
Volltext / DOI:
doi:10.1038/nm943
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14528298
Print-ISSN:
1078-8956
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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