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Title:

A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo.

Document type:
Journal Article; Article
Author(s):
Massberg, S; Gawaz, M; Grüner, S; Schulte, V; Konrad, I; Zohlnhofer, D; Heinzmann, U; Nieswandt, B
Abstract:
Platelet adhesion and aggregation at sites of vascular injury is crucial for hemostasis but may lead to arterial occlusion in the setting of atherosclerosis and precipitate diseases such as myocardial infarction. A current hypothesis suggests that platelet glycoprotein (GP) Ib interaction with von Willebrand factor recruits flowing platelets to the injured vessel wall, where subendothelial fibrillar collagens support their firm adhesion and activation. However, so far this hypothesis has not bee...     »
Journal title abbreviation:
J Exp Med
Year:
2003
Journal volume:
197
Journal issue:
1
Pages contribution:
41-9
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12515812
Print-ISSN:
0022-1007
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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