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- Titel:
A common genetic variant is associated with adult and childhood obesity.
- Dokumenttyp:
- Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
- Autor(en):
- Herbert, A; Gerry, NP; McQueen, MB; Heid, IM; Pfeufer, A; Illig, T; Wichmann, HE; Meitinger, T; Hunter, D; Hu, FB; Colditz, G; Hinney, A; Hebebrand, J; Koberwitz, K; Zhu, X; Cooper, R; Ardlie, K; Lyon, H; Hirschhorn, JN; Laird, NM; Lenburg, ME; Lange, C; Christman, MF
- Abstract:
- Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10... »
- Zeitschriftentitel:
- Science
- Jahr:
- 2006
- Band / Volume:
- 312
- Heft / Issue:
- 5771
- Seitenangaben Beitrag:
- 279-83
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1126/science.1124779
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/16614226
- Print-ISSN:
- 0036-8075
- TUM Einrichtung:
- Institut für Humangenetik
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