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Titel:

Three-dimensional maps of all chromosomes in human male fibroblast nuclei and prometaphase rosettes

Dokumenttyp:
Article
Autor(en):
Bolzer, A; Kreth, G; Solovei, I; Koehler, D; Saracoglu, K; Fauth, C; Müller, S; Eils, R; Cremer, C; Speicher, MR; Cremer, T
Abstract:
Studies of higher-order chromatin arrangements are an essential part of ongoing attempts to explore changes in epigenome structure and their functional implications during development and cell differentiation. However, the extent and cell-type-specificity of three-dimensional (3D) chromosome arrangements has remained controversial. In order to overcome technical limitations of previous studies, we have developed tools that allow the quantitative 3D positional mapping of all chromosomes simultane...     »
Zeitschriftentitel:
PLoS Biol
Jahr:
2005
Band / Volume:
3
Heft / Issue:
5
Seitenangaben Beitrag:
826-842
Sprache:
1
Print-ISSN:
1544-9173
TUM Einrichtung:
Institut für Humangenetik
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