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Titel:

Securin is not required for chromosomal stability in human cells

Dokumenttyp:
Article
Autor(en):
Pfleghaar, K; Heubes, S; Cox, J; Stemmann, O; Speicher, MR
Abstract:
Abnormalities of chromosome number are frequently observed in cancers. The mechanisms regulating chromosome segregation in human cells are therefore of great interest. Recently it has been reported that human cells without an hSecurin gene lose chromosomes at a high frequency. Here we show that, after hSecurin knockout through homologous recombination, chromosome losses are only a short, transient effect. After a few passages hSecurin(-/-) cells became chromosomally stable and executed mitoses n...     »
Zeitschriftentitel:
PLoS Biol
Jahr:
2005
Band / Volume:
3
Heft / Issue:
12
Seitenangaben Beitrag:
2127-2134
Sprache:
eng
Print-ISSN:
1544-9173
TUM Einrichtung:
Institut für Humangenetik
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