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Titel:

Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk.

Dokumenttyp:
Journal Article; Article
Autor(en):
Rivera, A; Fisher, SA; Fritsche, LG; Keilhauer, CN; Lichtner, P; Meitinger, T; Weber, BH
Abstract:
Age-related macular degeneration (AMD) is a multifactorial disease and a prevalent cause of visual impairment in developed countries. Risk factors include environmental components and genetic determinants. The complement factor H (CFH) has been the first major susceptibility gene for AMD identified within 1q32. Here, we focused on a second region of interest in 10q26 where a recent meta-analysis revealed strongest evidence for linkage to AMD at a genome-wide significance level. Within an interva...     »
Zeitschriftentitel:
Hum Mol Genet
Jahr:
2005
Band / Volume:
14
Heft / Issue:
21
Seitenangaben Beitrag:
3227-36
Sprache:
eng
Volltext / DOI:
doi:10.1093/hmg/ddi353
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16174643
Print-ISSN:
0964-6906
TUM Einrichtung:
Institut für Humangenetik
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