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Titel:

Linkage disequilibrium patterns and tagSNP transferability among European populations.

Dokumenttyp:
Journal Article; Article
Autor(en):
Mueller, JC; Lõhmussaar, E; Magi, R; Remm, M; Bettecken, T; Lichtner, P; Biskup, S; Illig, T; Pfeufer, A; Luedemann, J; Schreiber, S; Pramstaller, P; Pichler, I; Romeo, G; Gaddi, A; Testa, A; Wichmann, HE; Metspalu, A; Meitinger, T
Abstract:
The pattern of linkage disequilibrium (LD) is critical for association studies, in which disease-causing variants are identified by allelic association with adjacent markers. The aim of this study is to compare the LD patterns in several distinct European populations. We analyzed four genomic regions (in total, 749 kb) containing candidate genes for complex traits. Individuals were genotyped for markers that are evenly distributed at an average spacing of approximately 2-4 kb in eight population...     »
Zeitschriftentitel:
Am J Hum Genet
Jahr:
2005
Band / Volume:
76
Heft / Issue:
3
Seitenangaben Beitrag:
387-98
Sprache:
eng
Volltext / DOI:
doi:10.1086/427925
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15637659
Print-ISSN:
0002-9297
TUM Einrichtung:
Institut für Humangenetik
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