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Titel:

Common variants of LRRK2 are not associated with sporadic Parkinson's disease.

Dokumenttyp:
Journal Article; Article
Autor(en):
Biskup, S; Mueller, JC; Sharma, M; Lichtner, P; Zimprich, A; Berg, D; Wüllner, U; Illig, T; Meitinger, T; Gasser, T
Abstract:
Multiple mutations in the gene for the leucine-rich repeat kinase (LRRK2) cause autosomal dominant late-onset parkinsonism (PARK8). The Gly2019Ser mutation appears to be common in different populations. To investigate whether this novel gene influences the non-Mendelian sporadic form of Parkinson's disease, we genotyped 121 single nucleotide polymorphisms comprehensively covering the entire LRRK2 gene region in a set of 340 Parkinson's disease patients and 680 matched control subjects from Germa...     »
Zeitschriftentitel:
Ann Neurol
Jahr:
2005
Band / Volume:
58
Heft / Issue:
6
Seitenangaben Beitrag:
905-8
Sprache:
eng
Volltext / DOI:
doi:10.1002/ana.20664
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16254973
Print-ISSN:
0364-5134
TUM Einrichtung:
Institut für Humangenetik; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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