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Title:

Global gene expression in human myocardium-oligonucleotide microarray analysis of regional diversity and transcriptional regulation in heart failure.

Document type:
Journal Article; Article
Author(s):
Kääb, S; Barth, AS; Margerie, D; Dugas, M; Gebauer, M; Zwermann, L; Merk, S; Pfeufer, A; Steinmeyer, K; Bleich, M; Kreuzer, E; Steinbeck, G; Näbauer, M
Abstract:
To obtain region- and disease-specific transcription profiles of human myocardial tissue, we explored mRNA expression from all four chambers of eight explanted failing [idiopathic dilated cardiomyopathy (DCM), n=5; ischemic cardiomyopathy (ICM), n=3], and five non-failing hearts using high-density oligonucleotide arrays (Affymetrix U95Av2). We performed pair-wise comparisons of gene expression in the categories (1) atria versus ventricles, (2) disease-regulated genes in atria and (3) disease-re...     »
Journal title abbreviation:
J Mol Med
Year:
2004
Journal volume:
82
Journal issue:
5
Pages contribution:
308-16
Language:
eng
Fulltext / DOI:
doi:10.1007/s00109-004-0527-2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15103417
Print-ISSN:
0946-2716
TUM Institution:
Institut für Humangenetik
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