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Title:

Genomic profiling of viable and proliferative micrometastatic cells from early-stage breast cancer patients.

Document type:
Journal Article; Article
Author(s):
Gangnus, R; Langer, S; Breit, E; Pantel, K; Speicher, MR
Abstract:
PURPOSE: Metastases in distant organs are the major cause of death for cancer patients, and bone marrow is a prominent homing organ for early disseminated cancer cells. However, it remains still unclear which of these cells evolve into overt metastases. We therefore established a new approach based on the analysis of viable and proliferating cancer cells by single-cell comparative genomic hybridization. EXPERIMENTAL DESIGN: The bone marrow of early-stage breast tumor patients (pN(0)M(0)) was scr...     »
Journal title abbreviation:
Clin Cancer Res
Year:
2004
Journal volume:
10
Journal issue:
10
Pages contribution:
3457-64
Language:
eng
Fulltext / DOI:
doi:10.1158/1078-0432.CCR-03-0818
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15161702
Print-ISSN:
1078-0432
TUM Institution:
Institut für Humangenetik
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