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Titel:

Order of genetic events is critical determinant of aberrations in chromosome count and structure.

Dokumenttyp:
Journal Article; Article
Autor(en):
Fauth, C; O'Hare, MJ; Lederer, G; Jat, PS; Speicher, MR
Abstract:
A sequential acquisition of genetic events is critical in tumorigenesis. A key step is the attainment of infinite proliferative potential. Acquisition of this immortalization requires the activation of telomerase in addition to other activities, including inactivation of TP53 and the retinoblastoma family of tumor-suppressor proteins. However, the importance of the order in which these genetic events occur has not been established. To address this question, we used a panel of normal mammary fibr...     »
Zeitschriftentitel:
Genes Chromosomes Cancer
Jahr:
2004
Band / Volume:
40
Heft / Issue:
4
Seitenangaben Beitrag:
298-306
Sprache:
eng
Volltext / DOI:
doi:10.1002/gcc.20051
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15188452
Print-ISSN:
1045-2257
TUM Einrichtung:
Institut für Humangenetik
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